Multiple Sclerosis (MS) is a neurologic disease in which the immune system goes awry and attacks the brain and spinal cord.  It is the most common disabling neurologic condition amongst young adults, but its causes remain poorly understood. In short, the onset of MS probably occurs in individuals who are genetically susceptible and encounter certain environmental exposures that activate the immune system against the central nervous system. Our group is interested in understanding the influence of the genetic architecture of MS on the adaptive immune system and how it increases risk of developing MS.