EAE Experimental Immunology

The induction of immunologic tolerance is an important clinical goal in multiple sclerosis (MS) where its persistence is thought to be predominantly mediated by myelin-reactive memory T cells. Using experimental autoimmune encephalomyelitis (EAE), the animal model of MS, we have demonstrated that unlike conventional effector CD4+ T cells, memory T cells are less dependent on positive co-stimulatory signals for activation and induce severe and irreversible astrocyte and microglia activation in the spinal cord tissues of EAE mice (Elyaman et al, 2008).

EAE confocal2EAE confocal1

 

Our group is interested in dissecting the molecular mechanisms of memory CD4+ T cell resistance to tolerance in order identify predictors of therapeutic responses, which would be the first step toward individualized medicine.